Ahead of a daunting run of matches, Real Madrid have left Toni Kroos out of the squad for Sunday's game with Deportivo Alaves.
Santiago Solari's injury woes at Real Madrid continue to mount, with Toni Kroos joining Gareth Bale and Marco Asensio in the treatment room.
The late Johan Cruyff likened Davy Klaassen to Xavi and Toni Kroos, but the midfielder has dismissed the comparisons.
Joachim Low will be without Marco Reus or Toni Kroos when Germany take on Russia in a friendly match this week.
Santiago Solari's 19-man squad for his first match in charge of Real Madrid does not include Gareth Bale, Luka Modric, Toni Kroos or Isco.
Real Madrid's return to winning ways came as a relief to Toni Kroos, who is not used to such trials at the Santiago Bernabeu.
Real Madrid will hope the fit-again Isco can inspire them to a first win in five games as they host Levante in LaLiga.
Antoine Griezmann's brace consigned Germany to a sixth defeat of the year, something they have never suffered before.
France sit four points clear at the top of their Nations League group after Antoine Griezmann instigated a 2-1 win over Germany.
Toni Kroos moved to clarify comments he made about Germany team-mate Leroy Sane last month.