Real Madrid's return to winning ways came as a relief to Toni Kroos, who is not used to such trials at the Santiago Bernabeu.
Real Madrid will hope the fit-again Isco can inspire them to a first win in five games as they host Levante in LaLiga.
Antoine Griezmann's brace consigned Germany to a sixth defeat of the year, something they have never suffered before.
France sit four points clear at the top of their Nations League group after Antoine Griezmann instigated a 2-1 win over Germany.
Toni Kroos moved to clarify comments he made about Germany team-mate Leroy Sane last month.
Joachim Low came in for criticism from Michael Ballack, but Toni Kroos has leapt to the defence of Germany's head coach.
Germany winger Leroy Sane is not letting the disappointment of missing out on a World Cup - or comments by Toni Kroos - get to him.
Manuel Neuer, Thomas Muller and Toni Kroos' reaction to Mesut Ozil's Germany retirement has been questioned by the Arsenal star's agent.
Mariano Diaz was an unused substitute as Real Madrid drew at Athletic Bilbao, with Julen Lopetegui explaining why he ignored the striker.
While Lionel Messi and Cristiano Ronaldo have been rated 94 overall, only one of them could be ranked as the best player on the game.