Tottenham have Chelsea in their sights in the race for the top four and Son Heung-min urged Spurs to show no let-up.
Chelsea's 2-2 draw at Leicester City was no high-scoring flash in the pan - the Opta data lists 49 goals in the Blues' 13 away games.
Ilkay Gundogan missed a penalty and Oleksandr Zinchenko was sent off as Manchester City had a torrid afternoon at Tottenham Hotspur Stadium.
Tottenham succumbed to Southampton's late charge at St Mary's, with Sofiane Boufal cancelling out Son Heung-min's opener.
Dele Alli and Son Heung-min scored Tottenham's first league goals of 2020 in a 2-1 victory over Norwich City on Wednesday.
Tottenham and England are each set to suffer without Harry Kane, giving Jose Mourinho and Gareth Southgate some big decisions to make.
Tottenham's 1-1 draw with Middlesbrough was "not a disaster" according to Jose Mourinho, who bemoaned his side's injury problems.
Spurs will be without Son Heung-min for three games following his red card against Chelsea at the weekend.
The Premier League wants "appropriate action" to be taken against anyone found guilty of racist abuse in Tottenham's game with Chelsea.
Jose Mourinho says Son Heung-min has been punished enough after he was sent off in a derby loss against Chelsea on Sunday.