Southern Kings and Benetton Treviso both fell short on Welsh soil as Scarlets and Cardiff Blues earned Pro14 wins.
Lyon and Toulouse were both winners in Sunday's Top 14 action, with Patricio Fernandez impressing for the former.
England were quick out of the blocks against Ireland and Owen Farrell insists the team are happy with how things are "in-house".
Ireland were beaten 24-12 at Twickenham, with head coach Andy Farrell left to concede that England were much the better side.
Wigan Warriors edged the first half against Hull FC before pulling clear in the second period to earn a third win from four matches in 2020.
Eddie Jones' team selection for England's crunch Six Nations clash with Ireland raised eyebrows, but his side responded in style on Sunday.
Exeter plundered eight tries in a crushing victory over Northampton as they took another step closer to finishing top of the Premiership.
Wales look highly unlikely to retain their Six Nations title after a loss to France, but Wayne Pivac felt they were hard done by.
Bordeaux Begles gave another demonstration of their Top 14 title credentials with a bonus-point win over Clermont Auvergne.
After losing to Ospreys, Ulster bounced back by defeating Cheetahs, while Glasgow Warriors beat Dragons to move into third in Conference A.