Manchester United were thrashed 4-0 by Everton on Sunday as Ole Gunnar Solskjaer's side slumped to a fifth straight away defeat.
Arsenal risked losing ground in the race for the top four after they lost 3-2 at home to Crystal Palace.
A first home Premier League defeat since August will have come as a shock to Arsenal, with Crystal Palace the beneficiaries.
Liverpool will aim to be perfect until the end of the season, according to James Milner, as they hope for Manchester City to slip up.
Georginio Wijnaldum and James Milner scored the goals in Liverpool's win at Cardiff City, sending the Reds above Manchester City.
After Manchester United fell to a 4-0 loss at Everton, Ole Gunnar Solskjaer suggested some players do not care enough about the club.
Manchester United suffered a humiliating 4-0 defeat to Everton at Goodison Park on Sunday and Gary Neville fumed about their display.
Manchester United were blown away by Everton at Goodison Park, much to the delight of Toffees boss Marco Silva.
We take a look at the eye-catching Opta facts following Manchester United's embarrassing 4-0 Premier League defeat at Everton.
Manchester United were embarrassed by a rampant Everton at Goodison Park as their top-four chances were dealt a significant blow.