Manchester City took their place in the Champions League last eight as Raheem Sterling and Gabriel Jesus sealed a 2-1 win over Real Madrid.
Manchester City were gifted an opener against Real Madrid, with Raheem Sterling netting his 100th goal for the club in the process.
Eden Hazard will start against Manchester City, while David Silva is among the substitutes for Real Madrid's visit.
Chelsea face a tall order as they bid to come from 3-0 down against Bayern Munich, but Champions League comebacks are not so rare nowadays.
Lyon and Manchester City hold one-goal leads over European heavyweights Juventus and Real Madrid in the Champions League last-16.
Pierre-Emerick Aubameyang is reportedly close to extending his Arsenal contract.
Real Madrid defender Raphael Varane previewed Friday's Champions League last 16 second leg against Manchester City.
Gareth Bale disisihkan daripada skuad Real Madrid untuk menghadapi Manchester City dalam Liga Juara-Juara (UCL) kerana dia tidak mahu bermain, menurut Zinedine Zidane.
Manchester City have had an "average season", but Real Madrid will not find things easy at the Etihad Stadium, Clarence Seedorf says.
Zinedine Zidane said he left Gareth Bale out of Real Madrid's squad against Manchester City because the Welshman did not want to play.