World Cup winner Lewis Moody says Ellis Genge would be in his starting line-up to face Ireland with Mako Vunipola unavailable.
Alessandro Zanni comes back in for Dean Budd in Italy's only change for their clash with Scotland.
A wing injury crisis has led to Gael Fickou moving out wide against Wales, with centre Virimi Vakatawa back in the side.
Wayne Pivac has made two changes to his starting line-up to face France, Gareth Davies and Ross Moriarty getting the nod.
Eddie Jones says Manu Tuilagi should be fit to return against Ireland, while fellow centre Henry Slade will be monitored.
Caelan Doris has recovered from a head injury, but the Ireland number eight has to settle for a place on the bench against England.
Scotland, who are yet to score a try in this year's Six Nations, have made three changes to their XV to face Italy in Rome.
Hallam Amos returns to the Wales squad for this weekend's Six Nations clash with pace-setters France, replacing Cardiff team-mate Owen Lane.
Mako Vunipola has flown to Tonga and will not be available for England's Six Nations encounter with unbeaten Ireland this weekend.
Scotland have called up the fit-again Sam Skinner and Matt Fagerson ahead of their clash with Italy in Rome on February 22.