Jurgen Klopp could lose several key players to the rescheduled Africa Cup of Nations next January, and the Liverpool boss is furious.
Teams across Europe will again face disruption in the middle of the season, with the 2021 Africa Cup of Nations to take place in January.
Premier League stars Mohamed Salah, Sadio Mane and Riyad Mahrez have been shortlisted for the African Player of the Year award.
Mohamed Salah again tweaked his ankle in Liverpool's win over Manchester City and will now miss Egypt's next two matches.
Javier Aguirre was sacked after Egypt's AFCON failure, with Hossam El-Badry named his replacement as coach of the Pharaohs.
With Herve Renard quitting following a disappointing Africa Cup of Nations campaign, Morocco have appointed Vahid Halilhodzic.
Bernardo Silva sat out with "little muscular problems" at West Ham, but Manchester City called on Riyad Mahrez after his early return.
South Africa need a new head coach after Stuart Baxter resigned just weeks after leading them to an Africa Cup of Nations quarter-final.
After a disappointing AFCON campaign, which saw them knocked out in the last 16, Herve Renard has stepped down as Morocco coach.
Algeria coach Djamel Belmadi lauded his players and claimed they deserved their Africa Cup of Nations success after a narrow final win.