Manchester United's problems on the road continued with a 2-0 defeat at West Ham, while leaders Liverpool made it six wins out of six.
Half of the Premier League's 'big six' all lost at the weekend, with Liverpool and Manchester City showing they are way ahead of the rest.
Ainsley Maitland-Niles was sent off for Arsenal but late goals from Calum Chambers and Pierre-Emerick Aubameyang gave them all three points.
Unai Emery has made just one change to his starting XI from the side that drew with Watford last weekend for the visit of Aston Villa.
Could Thomas Tuchel replace Ole Gunnar Solskjaer at Manchester United? Reports suggest so.
Nicolas Pepe is yet to justify his hefty price tag at Arsenal and Unai Emery is working closely with the former Lille star.
Hector Bellerin and Kieran Tierney are closing in on a return to competitive action after they played for Arsenal's Under-23s.
Freddie Ljungberg's guiding influence is helping Arsenal teenager Bukayo Saka shine on the big stage
Despite being open to a move away, Shkodran Mustafi said there would be no "war" with Arsenal.
Manchester City playmaker David Silva is reportedly set to join MLS side Inter Miami in 2020.