Vernon Philander's international career ended in disappointment against England, which was a source of frustration for Faf du Plessis.
England captain Joe Root was encouraged by a series win in South Africa that saw a host of young players make key contributions.
Mark Wood took four wickets in the second innings as England defeated South Africa to seal the series with a day to spare.
England stayed on course for victory in the fourth Test and a 3-1 series success as the tourists set South Africa a record run chase target.
Vernon Philander's Test career is heading towards an unsatisfactory conclusion, the Proteas star fined on Sunday and struggling with injury.
South Africa will need to complete a world-record run chase to avoid defeat in the fourth Test with England.
England seamer Mark Wood successfully made his case for inclusion in the fourth Test and vindicated his selection on day two.
Mark Wood did damage with bat and ball as England took control of the fourth Test against South Africa on day two.
Ben Stokes has been fined and issued with one demerit point after an exchange with a supporter that he conceded was "unprofessional".
After being heard to use some choice language towards a fan in the crowd, England all-rounder Ben Stokes has apologised.