Australia internationals Kane Richardson and Adam Zampa are returning home from the Indian Premier League, while Ravichandran Ashwin has announced he is taking a break from the tournament.
Fast bowler Richardson played once in the 2021 edition, taking 1-29 from three overs in Bangalore's 10-wicket win over Rajasthan Royals on April 22.
Leg-spinner Zampa, however, did not feature for the Royal Challengers, who confirmed the departure of the duo for personal reasons.
"Adam Zampa and Kane Richardson are returning to Australia for personal reasons and will be unavailable for the remainder of #IPL2021. Royal Challengers Bangalore management respects their decision and offers them complete support," a statement on Twitter read.
Andrew Tye had become the first Australian to depart the IPL bubble on Sunday, a decision made by the Rajasthan Royals fast bowler over concerns about flights home amid a rise in COVID-19 cases in India.
The country has been setting global records for daily figures, with over 17million confirmed cases in total during the pandemic.
"I just thought I should try and get on the front foot and get home before I got locked out of the country," Tye told radio station SEN while in Doha awaiting to complete his journey to Australia.
"There's definitely concerns. A lot of guys have been in touch once they've realised I was leaving. Some of the guys are very interested in what route I took home and how I approached it."
A three-day snap lockdown was placed on the Perth and Peel areas of Western Australia last week amid concerns over coronavirus spreading within communities.
Ashwin, meanwhile, is leaving the Delhi Capitals squad to focus on helping his family during the coronavirus crisis.
"I would be taking a break from this year's IPL from tomorrow," he tweeted on Sunday. "My family and extended family are putting up a fight against COVID-19 and I want to support them during these tough times. I expect to return to play if things go in the right direction. Thank you."
Ashwin has taken one wicket and posted an economy rate of 7.73 runs per over in his five outings for the Capitals, who defeated Sunrisers Hyderabad on Sunday to make it four wins in five outings.