Tom Curry will miss the rest of England's November Tests after suffering an ankle injury during the 12-11 win over South Africa.
The Sale Sharks flanker was taken off early in the second half of the game at Twickenham on Saturday and was already considered a major doubt for this weekend's clash with New Zealand.
However, Curry – who won his fifth cap against the Springboks – will not only sit out the All Blacks game but also the upcoming fixtures against Japan and Australia.
"Tom Curry is not available this week and he'll be ruled out for the rest of the series as well," said England forwards coach Steve Borthwick.
"He injured his ankle but beyond that we don't know how long, but for the next three Test matches he'll be unavailable for us – everybody else is available for selection."
Second-rower Courtney Lawes and centre Manu Tuilagi, who missed the South Africa game with back and groin injuries respectively, look set to feature on Saturday.
England coach Eddie Jones told the media on Monday he was "cautiously optimistic" over the pair ahead of the clash with the world champions.