George Furbank will make his England debut in their Six Nations opener against France at full-back following an injury to Anthony Watson.
Watson was not considered for selection due to a calf issue he entered England's training camp with and Eddie Jones has given Northampton Saints back Furbank the nod.
Elliot Daly will consequently start on the left wing and Jonny May on the opposite side at the Stade de France on Sunday.
George Ford has been handed the fly-half berth with Owen Farrell named at inside centre, while Tom Curry gets the number eight spot in the absence of the injured Billy Vunipola.
Luke Cowan-Dickie was scheduled to re-join the squad in Paris on Friday after being granted leave for personal reasons and was among the replacements. Uncapped prop Will Stuart was also named on the bench.
Jones said: "It has been a massively exciting week for us. It is the start of the Six Nations, the best rugby tournament in the world. We have had a great preparation in Portugal with a quality training week this week.
"We have really worried about ourselves, getting ourselves right. We have picked a strong forward pack which is part of the England way and an exciting backline with young George Furbank playing his first Test at full-back.
"France can expect absolute brutality from England, we are going to go out there to make sure they understand what Test rugby is. It is about being brutal, it is about being physical and it is about dominating the set piece."
England: George Furbank, Jonny May, Manu Tuilagi, Owen Farrell, Elliot Daly, George Ford, Ben Youngs; Joe Marler, Jamie George, Kyle Sinckler, Maro Itoje, Charlie Ewels, Courtney Lawes, Sam Underhill, Tom Curry.
Replacements: Luke Cowan-Dickie, Ellis Genge, Will Stuart, George Kruis, Lewis Ludlam, Willi Heinz, Ollie Devoto, Jonathan Joseph.