Props Kyle Sinckler and Mako Vunipola have returned to the England squad for the Six Nations encounter with Italy at Twickenham on Saturday.
British and Irish Lions duo Sinckler and Vunipola missed the 11-6 Calcutta Cup defeat to Scotland on the opening day of the tournament due to suspension and an Achilles injury respectively.
They will be available to beef up the defending champions' pack against an Azzurri side smarting from a 50-10 hammering at the hands of a rampant France at Stadio Olimpico.
Harry Williams and Tom West will not feature for Eddie Jones' side after they were released to return to their clubs.
The Red Rose never got going in a poor performance versus dominant Scotland, but they won the tournament last year after losing their opening match to France and number eight Billy Vunipola said they can respond again.
He said: "It is frustrating. I won't lie. But this happened last year, and we managed to pull it back so it's massive for all of us to make sure we get around each other and whatever we need to fix this week we do as soon as possible.
"We only have a week to do it, which is probably the best thing for us. We don't have a fallow week to let that settle in and frustrate us.
"You never really forget these days, you never really forget these moments, and to be honest I don't really want to forget them.
"I want to move on from it, but I don't want to forget it as it keeps you sharp. Losing like this at Twickenham is never what you dream of."