England start their quest to retain the Six Nations title against Scotland on Saturday just over three months after they were crowned champions.
The Red Rose dethroned Wales at the end of October, pipping France on points difference in a dramatic finale to a tournament that ended almost nine months after it started due to the COVID-19 pandemic.
Eddie Jones' side are favourites to win the competition again, but Les Bleus are also well fancied to end an 11-year wait for Six Nations glory and face Italy in the first match.
England do battle with Scotland for the Calcutta Cup at Twickenham, with Wales and Ireland locking horns in Cardiff on Sunday.
Ahead of the opening round, we preview the upcoming matches with help from Opta.
ITALY v FRANCE
France have won 19 of their 21 previous Six Nations matches against Italy (L2), including their last seven in a row. Their two defeats in that time both came in Rome, in 2011 and 2013.
Italy have lost their last 27 Six Nations matches, the longest losing streak in the history of the competition. Their last victory came at Murrayfield against Scotland in 2015, while they have not won at home since 2013.
Les Bleus achieved a cumulative points difference of +31 in the first 20 minutes of their 2020 Six Nations matches. No other side managed a positive double-digit points difference in that period of matches, but Italy had a -39 difference.
ONES TO WATCH
France wing Teddy Thomas scored a try in his last Test against Italy and is capable of lighting up the tournament. He can get off to a storming start in Rome.
Paolo Garbisi caught the eye at fly-half last year after being handed his debut against Ireland in October. Hopefully for his country, there is still much more to come from the 20-year-old.
ENGLAND v SCOTLAND
The last time England hosted Scotland in the Six Nations they drew 38-38 two years ago. Scotland clawed back the biggest ever half-time deficit (-24 pts, 7-31) by a side to avoid defeat in the tournament’s history, almost snatching victory before a late George Ford try denied them.
Scotland have never beaten England at Twickenham in the Six Nations (D1, L9), their last victory against them the Red Rose at the London venue came in 1983 in the Five Nations (22-12).
Gregor Townsend's side concluded the 2020 edition by winning their last three games in a row, their best run in the Championship since Italy joined in 2000.
ONES TO WATCH
England captain Owen Farrell has scored exactly 1,000 Test points, one of just six men to reach that milestone. He is just four points away from reaching a century against Scotland.
Finn Russell returns to the Scotland side and the creativity provided by the fly-half will be key for Townsend's men.
WALES v IRELAND
Wales have lost their last two home games in the Six Nations, the last time they suffered three consecutive defeats at home was in 2002-03. Wayne Pivac's side have lost their last four games in the competition, their worst streak since 2006-07 (L5).
No team scored more tries than Ireland in the Six Nations last year (17, along with France), four of those were launched from the back of a scrum. Wales (2) were the only other side to score multiple tries following a scrum.
Ireland scored seven tries in the final quarter of their fixtures in 2020, more than any other side. Wales, meanwhile, scored the joint-second most in that period (6, level with England).
ONES TO WATCH
Louis Rees-Zammit turned 20 this week and the Wales wing can celebrate in style with a livewire display at the Principality Stadium.
Ireland centre Garry Ringrose had terrible luck with injuries last year, but he is ready to fire on all cylinders in 2021.