Tony Finau and Cameron Champ head into the weekend 13 under through 36 holes, two strokes clear alongside Viktor Hovland and Kris Ventura.
First-time champion Joel Dahmen reigned supreme in the Dominican Republic on Sunday.
After a tough 2020 so far, Hudson Swafford leads the Corales Puntacana Resort and Club Championship.
Four players sit atop the leaderboard in the Dominican Republic on Thursday.
Brooks Koepka's caddie has tested positive for coronavirus and the four-time major champion will not play at the Travelers Championship.
Graeme McDowell finished two shots clear of Dustin Johnson to win in Saudi Arabia and end a long wait to prevail again on the European Tour.
Graeme McDowell heads into the final round of the Saudi International top of the leaderboard after overnight leader Victor Perez fell away.
Brooks Koepka, Dustin Johnson and Phil Mickelson may struggle to land the Saudi International title after Victor Perez took control.
Harold Varner and Ryan Palmer were joined by four other pairs at the top of the QBE Shootout leaderboard.
There has been plenty of success for both Northern Ireland and the Republic of Ireland in major championships over the past 12 years.