Real Madrid defender Marcelo injured his neck during the weekend win against Levante and is now a major doubt to face Paris Saint-Germain.
Paris Saint-Germain forward Neymar converted from the penalty spot against Nice to take him to 50 goals for the French champions.
Monaco midfielder Cesc Fabregas left the field early on against Reims with a calf injury and is facing a possible spell on the sidelines.
The 18-year-old phenom made his debut for the USMNT in March and scored his first goal in May.