Fresh from a famous Calcutta Cup triumph, Scotland will look to make it two wins out of two when they do battle with Wales.
After victory over England in the opening round of the Six Nations, Scotland make three changes for the visit of Wales to Murrayfield.
After defeat to Scotland in the opening round, Eddie Jones has drafted in some familiar faces to take on Italy.
Ireland star Johnny Sexton was left angered by comments regarding his concussion record made by a French doctor.
New Zealand World Cup winner Aaron Smith says watching Antoine Dupont is helping him to improve his game.
Ireland will be without Peter O'Mahony until the final game of the Six Nations following his red card against Wales.
British and Irish Lions duo Kyle Sinckler and Mako Vunipola make a welcome return to England's squad after the loss to Scotland.
Gregor Townsend has added D'Arcy Rae, Charlie Shiel and George Taylor to Scotland's squad to take on Wales at Murrayfield.
Wayne Pivac will have to reassemble his Wales squad for the game with Scotland after their win over Ireland came at a cost.
Peter O'Mahony was sent off as Wales held off a spirited 14-man Ireland side to start the 2021 Six Nations with a hard-fought win.