British and Irish Lions duo Kyle Sinckler and Mako Vunipola make a welcome return to England's squad after the loss to Scotland.
Gregor Townsend has added D'Arcy Rae, Charlie Shiel and George Taylor to Scotland's squad to take on Wales at Murrayfield.
Wayne Pivac will have to reassemble his Wales squad for the game with Scotland after their win over Ireland came at a cost.
Peter O'Mahony was sent off as Wales held off a spirited 14-man Ireland side to start the 2021 Six Nations with a hard-fought win.
There were conflicting emotions for respective Scotland and England coaches Gregor Townsend and Eddie Jones after their Six Nations clash.
Scotland dominated lacklustre champions England to finally win at Twickenham and get their hands on the Calcutta Cup.
Defending champions England were punished for a lacklustre display as an inspired Scotland got their Six Nations campaign off to a flyer.
Antoine Dupont turned in a star performance as France cruised to an emphatic 50-10 victory over Italy in their Six Nations opener.
Scotland produced an astonishing fightback in their last trip to Twickenham and are eyeing another shock against England this weekend.
Wales will be without wing Josh Adams for their first two games of the Six Nations after he attended a family celebration last weekend.