England will be out to put a dent in Wales' Six Nations title hopes in Cardiff and enhance their own chances of retaining the trophy.
Wales will be out to make it three wins from three in the 2021 Six Nations when they face England on a milestone occasion for George North.
Just a day after receiving the green light for the game to go ahead, France's clash with Scotland has been postponed.
There have been no more positive COVID-19 tests in the France squad over the past two days, so they are set to take on Scotland in Paris.
Ireland could welcome back Johnny Sexton on Saturday, with the experienced fly-half still as enthusiastic as ever.
With 14 confirmed coronavirus positives, France's Six Nations match with Scotland on Sunday may well be postponed.
Six Nations leaders France are up to nine coronavirus positives, with Julien Marchand and Arthur Vincent ruled out of facing Scotland.
Six Nations leaders France are struggling to contain a coronavirus outbreak - Mohamed Haouas and Gabin Villiere the latest to test positive.
After three members of the France backroom team tested positive for COVID-19, Antoine Dupont returned a positive result on Friday.
France scrum coach William Servat was confirmed as the third member of the backroom team to test positive for coronavirus.