The South Africa bowlers needed only 54 overs to bowl West Indies out and are well on course for a 2-0 Test series whitewash.
South Africa recovered from 37-3 to reach 218-5 on day one of the second Test with West Indies.
West Indies were humiliatingly beaten in the first Test and South Africa will look to exploit their batting frailties to win the series.
South Africa completed the job early on in Saturday's session thanks to some impressive bowling from Kagiso Rabada.
A sixth Test century for Quinton de Kock drove home South Africa's dominance of the first Test against West Indies in St Lucia.
Teenage debutant Jayden Seales led a much-needed West Indies fightback against South Africa, but the Proteas were in control after day one.
Jason Holder is part of the West Indies squad to face South Africa, but it will be Kraigg Brathwaite who leads the team.
A big-name omission from Warren Gatland's original squad, Kyle Sinckler has been called up to replace the injured Andrew Porter.
Morne Steyn sealed South Africa's win over the British and Irish Lions in 2009, and after a long absence, he is back in a Springboks squad.
AB de Villiers will not be making a comeback with South Africa after negotiations over a potential return did not end in an agreement.