Scrum-half Kieran Hardy has been released from the Wales Six Nations squad, while Dan Biggar also has an injury problem.
Maro Itoje received backing from Eddie Jones after England's loss to Wales, while Ellis Genge has received death threats on social media.
Pascal Gauzere awarded Wales two controversial first-half tries, but Eddie Jones and Owen Farrell did not vent their fury at the referee.
Wales coach Wayne Pivac had little sympathy for England after his side benefitted from some contentious officiating in Saturday's clash.
Wales sealed a triple crown as Wayne Pivac's side saw off reigning Six Nations champions England in an action-packed encounter on Saturday.
England will be out to put a dent in Wales' Six Nations title hopes in Cardiff and enhance their own chances of retaining the trophy.
George North akan menjadi pemain termuda dalam dunia ragbi mencecah penampilan antarabangsa ke-100 selepas Wales menamakannya dalam barisan utama perlawanan menentang England dalam Kejohanan Ragbi Enam Negara esok.
Wales will be out to make it three wins from three in the 2021 Six Nations when they face England on a milestone occasion for George North.
Wales fought from 14 points down to defeat Scotland, but Wayne Pivac does not think all the team's issues have been overcome.
Louis Rees-Zammit scored two tries and set up another as Wales claimed a slender victory over Scotland at Murrayfield on Saturday.