After defeat to Scotland in the opening round, Eddie Jones has drafted in some familiar faces to take on Italy.
Mako Vunipola has joined Jonathan Joseph on the sidelines ahead of England's clash with France in the Autumn Nations Cup final.
Owen Farrell booted 14 points and could afford to miss a couple of kicks as Eddie Jones' England won comfortably enough in Wales.
Saracens may be heading to the second tier but Owen Farrell is staying put, the fly-half opting to remain at Allianz Park.
Maro Itoje and Mako Vunipola have not committed to Saracens for next season, but John Mitchell is confident they will make the right call.
England overlook Mako Vunipola as a coronavirus precaution, yet he will play for Saracens against Leicester Tigers.
Mako Vunipola could play for Saracens this weekend, but England were advised not to take any risks following the prop's trip overseas.
Saracens have clarified Mako Vunipola has not been in self-isolation and is free to play Leicester Tigers this weekend.
Initially ruled out of the Wales Six Nations game for "medical reasons", England confirmed Mako Vunipola is in self-isolation.
England will not have Mako Vunipola back to face Wales, with the prop ruled out for the Six Nations encounter at Twickenham.